浙江大学高长有教授、庄乐南研究员团队《Biomaterials》：多功能弹性体心肌补片抑制心肌梗死

    心肌梗死（MI）发病率高，严重威胁患者生命。心肌梗死后，部分患者中会出现左心室病理性重构，进而引发心力衰竭。左心室重构存在坏死期、炎症期、纤维化期三个连续的阶段。心肌缺血发生后，第一个阶段为细胞坏死阶段，大量的心肌细胞死亡并释放过量活性氧（ROS）和其他细胞内容物到组织微环境中，刺激促炎细胞因子的分泌并招募免疫细胞到受损心肌组织。第二个阶段为炎症阶段，心梗后的炎症微环境会破坏细胞稳态，造成更加严重的氧化损伤，进而加重炎症反应。过量产生的ROS是该阶段病理机制中的重要介质之一。最后一个阶段为纤维化阶段，其主要特征是胶原和细胞外基质沉积。研究表明，降低心梗后的炎症与纤维化水平可有效抑制左心室病理性重构。此外，弹性体心脏补片通过为梗死及周边心肌提供机械支持，在防止左心室重构方面显示出巨大潜力。因此，通过调节坏死期、炎症期和纤维化期的病理过程并为梗死心肌提供力学支撑，有望进一步提高心肌梗死的治疗效果。     近期，浙江大学高分子科学与工程学系高长有教授、朱旸研究员和动物科学学院庄乐南研究员团队利用多功能弹性体心肌补片有效抑制了心肌梗死后的左心室重构。将ROS响应的聚酮缩硫醇（PTK）和含有不饱和双键的聚富马酸丙二醇酯（PPF）作为软段，并用酮缩硫醇二胺（TK）扩链得到线性ROS响应性可降解不饱和聚氨酯（PFTU）。通过其主链上高密度的碳碳双键进行REDV多肽的修饰（PR），制成含有瑞舒伐他汀药物的多孔心肌补片（PRR）（图1）。该补片除提供机械支持作用外，PFTU中的酮缩硫醇能迅速消耗ROS、减少心肌细胞凋亡、提高巨噬细胞M2/M1表型的比例并降低炎症因子TNF-α的表达水平，改善心梗组织微环境。促血管生成的REDV多肽，加快了多孔补片内细胞的渗透和新血管的形成，提高了梗死心肌和补片内的血管密度，并诱导血管成熟。此外，由于瑞舒伐他汀兼具抗炎和促血管生成的作用，这些治疗效果得到了增强。植入PRR多孔补片可以帮助梗死心脏维持与假手术组类似的心脏功能、心室大小、壁厚和血管成熟度。 <img alt="" 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课题组年终乒乓球对抗赛成功举行

　　 2010年1月28日实验室内部乒乓球比赛于高分子楼一楼活动大厅举行。比赛分为团体赛和个人赛两部分举行。     （高老师在比赛中）     团体赛中两队选手水平相当，难分高下，经过一个多小时的激烈角逐，仝老师和刘老师领衔的红队力压高老师和马老师率领的黑队，取得了最终的胜利。       （冠军队合影）     （亚军队合影） 　　随后的进行的个人对抗赛更是精彩纷呈，观众欢呼声此起彼伏。攻守兼备的于大海同学，经过三轮淘汰赛，技压群雄夺得了冠军。女将也不示弱，劳丽红同学获得了季军。              颁奖嘉宾--高老师（后左）与单人对抗赛冠亚季军合影 冠军—于大海（后右）亚军—佘书鹏（前中）季军—吴兴杰（前左）劳丽红（前右 ）   　　在一片欢声笑语中，比赛落下帷幕。比赛的成功得益于高老师的大力支持，刘幸同学的精心策划，马春燕助理的辛勤准备，老师、同学们的积极参与。乒乓球比赛展现了实验室同学的积极向上，全面发展的良好风貌。我们期待着老师、同学们在新的一年中在各方面都取得新的进展，更上一层楼！ 摄影：谢黎黎  报道：谢黎黎

热烈祝贺课题组四朵金花获得博士（硕士）学位

    3月的杭州，大地回春，花香溢满校园。我组织修复与再生医用高分子材料课题组内四朵金花胡玲、彭采宇、劳丽红、邱媛顺利通过答辩，获得了博士和硕士学位。她们工作时忙碌的身影，生活中的甜美微笑，都将成为我们难以忘却的回忆。     2010年3月8日——第一百个国际妇女节。在这特殊的一天，两位博士生胡玲和彭采宇，顺利通过了博士毕业论文答辩。在从14：00到16：30持续两个半小时的答辩中，两位女博士简要陈述了攻读博士学位期间的完成的工作，专家教授高度评价了论文工作的意义并真对她们工作中的问题提出了中肯建议。随后答辩委员会主席翁文剑教授郑重宣布胡玲和彭采宇获得博士学位，全场响起热烈掌声。 胡玲答辩陈述、彭采宇回答专家提问 答辩委员会专家们聚精会神听取博士生陈述报告（左起陈义镛教授、沈家骢院士、方征平教授） 胡玲与答辩委员会委员合影 彭采宇与答辩委员会委员合影     3月10日上午，两位硕士生劳丽红、邱媛迎来了学生时代的一次重要时刻——硕士学位论文答辩。与会答辩委员专家有：主席——翁文剑教授，委员——高长有，胡巧玲，计剑，孙景志教授等。两位硕士生将两年多来实验积累的丰硕成果展示在短短的几十页幻灯片中，页页翻动，给同学们带来了心灵的震撼。答辩委员会专家教授们逐一提问，两人都巧妙化解，敏捷的思维和广博的学识，展现无余。     劳丽红听取专家建议、邱媛作陈述报告 生物大分子研究所八位硕士生与答辩委员会委员合影     最后，再次热烈祝贺我组四位金花胡玲、彭采宇和劳丽红、邱媛分别获得了博士和硕士学位。愿她们在未来的工作岗位和学习生活中，继续发扬刻苦钻研的精神，取得更好的成绩！ 通讯员：  谢黎黎

课题组王玮同学顺利通过博士答辩

　　2010年06月09日下午，课题组王玮同学的博士论文答辩在高分子楼附楼二楼会议室举行。答辩委员会成员包括北京大学前沿交叉学科研究院生物材料和组织工程中心主任、国家药监局中检所医疗器械质量监督检验中心原主任奚廷斐教授、浙江大学医学院欧阳宏伟教授、材料系翁文剑教授、高分子系徐志康教授和高长有教授，其中由奚廷斐教授担任主席。   王玮陈述学位论文研究内容 　　王玮同学的博士论文题目是“PLGA/纤维蛋白凝胶复合支架的制备及其用于软骨再生的研究”，论文涉及到材料制备与表征、分子生物学研究、动物实验等多方面内容，属于多学科交叉的领域。在本组已有的“水凝胶填充多孔支架”基础之上，王玮同学创新性地引入具有多分化潜能的间充质干细胞、促软骨分化生长因子、可表达促分化因子的基因等多种组分，构建出了具有生物活性的复合体系，并应用于兔骨-软骨全缺损的修复中，取得了良好的效果。相关研究成果In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes已发表在生物材料领域权威学术期刊Biomaterials上．   王玮构建的软骨修复体系示意图   　　来自北京大学前沿交叉学科研究院的奚廷斐教授，以及来自我校医学院的欧阳宏伟教授等专家对王玮的工作给予了高度的评价，并提出了很多中肯的意见。师生们就论文当中的亮点和存在的问题展开了积极地讨论。 　　祝愿王玮博士在新的工作平台上能够不断前进！     通讯员：李博

热烈祝贺我课题组获得首届高分子系“聚 合”杯拔河比赛冠军

　　2010年6月11日下午，由高分子系党总支举办的首届高分子系“聚•合”杯拔河比赛在高分子大楼前成功举行。 　　我课题组作为生材一组派出超豪华的三三二阵容，三名男老师（高长有老师、马列老师、仝维鋆老师），三名男生（王伟、李丹、刘幸），两名女生（马春燕助理、谢黎黎）。有高老师和马老师两位重量级老师的鼎力加盟，生材一组的士气锐不可挡。参赛的12支队伍中，我组以平均身高大于175cm，平均体重大于80kg的综合实力傲视群雄。在队长韩璐璐的领导下，小组赛中队员们牛刀小试，2：0轻取对手。队员们在随后淘汰赛中渐入佳境，连下三局，勇夺冠军。   在比赛中，老师和同学们聚精会神，紧绷的绳子牵动每个人的神经。   一旁的啦啦队队员们在声嘶力竭地呐喊   比赛结束，高老师和马老师擦擦额头微微渗出的汗滴，和蔼地微笑   冠军队颁奖合影   摄影：朱旸 王秉    通讯员： 谢黎黎 

张裕英博士顺利通过博士后出站考核

 　　2010年06月21日下午，张裕英博士的博士后出站考核报告在高分子楼附楼二楼会议室成功举行。考核委员会由我校生命科学学院细胞与遗传学研究所副所长王金福教授，高分子科学与工程学系孙景志教授、朱宝库教授、蒋宏亮教授及高长有教授组成，其中王金福教授担任主席。 　　张裕英博士于08年6月毕业于武汉大学生命科学学院，同年7月进入我校进行博士后研究工作，在站期间的研究方向为胶体微粒与细胞的相互作用。涉及胶体微粒的合成与修饰；细胞对粒子的识别与吞噬；胶体微粒在细胞内的分布与转运；纳米粒子的毒性及对细胞生长、粘附、迁移和凋亡等生理功能的影响。整块工作内容翔实，具有较强的交叉性及前瞻性，极大地丰富和拓展了本课题组在微粒与细胞层面的研究工作。张博士以扎实的生物学理论知识及娴熟的生物学实验技术为我组在生物学表征方法学方面的建立贡献良多，对今后的工作具有重要意义。 张裕英博士在回答专家问题   　　张裕英博士的出站报告以其新颖的研究内容吸引了广大组内外同学前来聆听，会场内座无虚席。在为时一个多小时的汇报过程中，张裕英博士简要陈述了博士后期间的完成的工作，专家教授高度评价了论文工作的意义并真对她工作中的问题提出了中肯建议。随后考评委员会主席王金福教授郑重宣布张博士博士后阶段工作优秀，顺利通过考评出站。 与考评委员会委员合影留念 　　张裕英博士平日里为人谦和，乐于助人，忘我工作，深受老师同学的喜爱和好评。我们由衷祝愿张博士在今后的工作和生活中一切顺利！           摄影：韩元元   通讯员：于大海 王秉

朱一和郭瑞同学顺利通过博士学位论文答辩！

　　2010年09月10日——教师节，在这个具有纪念意义的日子里，我课题组朱一和郭瑞同学顺利通过了他们的博士论文答辩。参加答辩的委员有重庆大学的蔡开勇教授、浙二医院皮肤科主任郑敏教授、生医系的王平教授、化学系副主任黄飞鹤教授、化学系胡吉明教授、高分子系的徐志康教授以及高长有教授，由徐志康教授担任答辩委员会主席。 　　朱一同学的研究方向为复合胶束结构的中空微胶囊体系的制备和性能研究，曾作为中德联合培养研究生赴德国马普胶体与界面研究所交流学习一年，读博期间已发表多篇论文。他短短几十分钟的答辩陈述得到了在场的专家和同学的一致好评，在面对答辩委员提问时他更是思路清晰，体现了扎实的专业知识功底，同时在场的专家也给予了他很多中肯的意见和建议，并希望他在今后的工作和学习中能有更好的表现。 朱一同学回答专家的问题 答辩委员会专家们展开激烈讨论 　　郭瑞同学在校期间工作努力、表现突出，他的博士论文题目是“基因活性真皮替代物的构建及其用于皮肤再生的研究”，毕业前就已经有“The healing of full-thickness burns treated by using plasmid DNA encoding VEGF-165 activated collagen-chitosan dermal equivalents”和“Enhanced angiogenesis of gene-activated dermal equivalent for treatment of full-thickness incisional wounds in a porcine model”两篇文章发表到了生物材料领域权威学术期刊Biomaterials上。在展示完自己的工作成果之后，答辩委员会的专家们开始逐一提问，他严谨的回答展现了对课题本身的深入理解，专家对他的工作也给予了高度评价。      郭瑞博士陈述答辩内容并认真听取专家意见   　　答辩结束后他们共同祝愿老师们教师节快乐，最后由徐志康教授宣布二人顺利通过了博士论文答辩，大家热烈鼓掌表示祝贺。     徐志康教授祝贺朱一和郭瑞顺利通过博士答辩   答辩委员会全体成员与两位同学合影留念 　　两位同学在读博期间给课题组的同学们树立了很好的榜样，让我们向他们看齐，一起为课题组的发展共同努力，在此也衷心祝愿两位博士的未来更加美好！ 通讯员： 刘云云     摄影：马春燕

课题组开展迎新生破冰活动

本月18日，我课题组在银乐迪KTV举办了一次迎新生K歌活动，借以帮助新生们顺利融入我们课题组的大家庭当中。   期间，大伙儿积极踊跃地展现自我，韩璐璐、刘幸等同学更是以惊艳的歌喉打动了全场，将活动气氛进一步推向高潮。同时K歌之余，在强调团体意识的三国杀游戏中，大家积极思考，寻求相互配合，“杀”声四起。游戏胜与败，也是一种学习的过程。   经过四个小时的欢 唱，破冰活动顺利地落幕，各位同学们又将重新回到学习和科研活动中去。希望通过这次活动，新生们也能够尽快适应研究生的生活，认识到自己作为课题组一员的 重要责任，与大家共同建设一个更出色的集体。最后预祝本课题组在高长有老师的带领下，不断开拓发展，蒸蒸日上。

记课题组绍兴一日游

　　2010年12月12号，课题组在绍兴开展了冬游活动。参与此次活动的包括课题组老师、研究生同学、以及从事科研训练的大三本科生同学，一行共四十余人。 　　虽然天气有雨并且略显阴冷，但老师同学们热情高涨。车行途中一路欢歌笑语；高老师更是兴致勃勃地为大家一展歌喉，同学们也有幸领略到了老师们的才艺风采。 　　 　　大家首先游览了国家首批“AAAA”级旅游区——柯岩风景区。柯岩景区久负盛名，姿态各异的石宕、石洞、石潭、石壁等石景，堪称鬼斧神工；宽广宁和的湖景，让大家仿佛置身画卷中。走进鲁镇，但见粉墙黛瓦的古居、枕河临街的店铺、静穆庄严的寺庙、千姿百态的石拱桥、古色古香的石板路、纵横交错的深水巷，绍兴的桥文化、石文化、水文化、酒文化、名士文化扑面而来。中餐后，老师同学们又游览了会稽山-大禹陵景区和鲁迅故里。大禹陵为国家级重点文物保护单位，景区依山傍水，气势恢宏，景色秀丽。鲁迅故里是一条独具江南风情的历史街区，大家充分品味了鲁迅笔下风情人物以及感受鲁迅当年生活情境的真实场所。   越王勾践像前的集体照 　　短短的一天行程，紧凑而充实；大家在活动中体验愉悦、放松身心、增进情谊。我们相信，在全体师生的热情参与和努力进取之下，课题组的各项活动和工作，都将开展得越来越好。 通讯员：刘幸

我组与国立台湾大学杨台鸿教授课题组进行双边交流！

　　2010年12月17日，杭州刚被一场少有的大雪穿上了皑皑银装，显得分外妖娆。这天上午，在高分子大楼228，国立台湾大学杨台鸿教授课题组与我们课题组进行了一场学术交流活动。杨教授是台湾大学医学工程研究所所长，其课题组主要研究内容涉及组织工程与再生医学中的多个领域（如唾液腺、毛囊再生、神经干细胞分化等）以及生物材料产品的开发（如人工皮等）。在交流会上做报告的有来自台湾大学的邵宏仁博士、陳啟瑞博士和鍾易辰、李亦宸、陸瑞男同学和我们课题组的韩璐璐、李丹、王志鹏、刘幸、佘书鹏、于大海同学。大家在报告进行过程中积极地提问、交流、相互学习，对彼此的研究方向都有着浓厚的兴趣。      杨老师赠与高老师台大的文化衫    我组同学在向台大同学提问      台大同学在向我组同学提问       所有老师及做报告的同学合影留念   　　下午，杨老师又做了一场名为From biomaterials to tissue engineering的公开学术报告，报告内容精彩，引人入胜，杨老师的演讲深入浅出，通俗风趣，获得了听众的阵阵掌声。   杨台鸿教授在作报告        通讯员：任探琛

生物医用大分子所举行新年联欢

　　2011年1月7日，生物医用大分子研究所庆祝新年联欢活动在灵峰山庄举行。研究所所长沈家骢院士、副所长高长有教授和计剑教授、陈义镛教授等人都出席了本次活动。除了本研究所的全体老师和同学之外，系主任徐志康教授、系党委王庆文书记以及系办的众位老师也应邀参加了活动。 　　活动在18：00正式开始，高老师作为生医所的副所长对生医所过去一年所取得的成绩进行了简要的介绍：计剑教授荣获国家杰出青年科学基金，一项科技项目获得省科学技术二等奖。应邀参加的徐志康教授对过去几年生医所的发展壮大表达了他的欣喜之情。身为生物医用大分子所的所长，沈先生除了对研究所过去一年取得的成果表示肯定之外，也提了一些建设性的意见，并向大家表达了美好的新年祝愿。 　　接着，由王书记主持，陈教授面对着蛋糕许下心愿，在场的老师和同学们齐唱《祝你生日快乐》，祝贺陈老师的80岁寿辰。祝他老人家生日快乐！ 　　此外，各位老师也纷纷拿出自己的绝活登台献艺，同学们也积极主动的上台表演，精彩的节目赢得了大家的阵阵掌声，整个大堂里充满了欢声笑语。 　　最终本次联欢活动在轻松愉快的气氛中结束了。 　　希望大家能够在新的一年里再创佳绩！ 通讯员：姜朋飞   

2011年1月7日研究所新年联欢

课题组举行2010-2011秋冬学期总结会

  　　组织修复与再生医学课题组本学期总结会于2011年1月20日上午8点30份准时召开，课题组全体老师和研究生出席。每个人将5个月的辛勤工作浓缩为5分钟的口头报告，10页左右的精彩PPT展现给大家。其间掌声不断，高潮迭起。老师和同学们在回顾过去的累累硕果时，也定下了来年的新计划。高老师的总结还向我们提出了发人深省的思考：目标和过程孰重孰轻，同学们积极响应发表个人观点，妙语连珠。总结会的最后部分进行了第二届超勤奖的颁发，12名在过去一学期中工作勤奋刻苦的同学获奖，高老师为同学们颁奖，随后获奖同学与全体老师合影留念。 　　杭州连续下了一天一夜的大雪，系楼附件的桂花、香樟和竹子都被大雪压弯了腰。在高老师的倡议下，全体师生一起动手，清除树上的积雪，让它们重新站直了腰。大家以这种公益行动的方式为2010-2011秋冬学期划上了圆满的句号。 　　下午师生们踏雪步行到银乐迪K歌放松心情，各位老师和同学们都一展歌喉，尤其是马列老师和韩璐璐同学，应当是师生中当之无愧的“麦霸”。傍晚，大家在严州府聚餐，欢度新年和庆祝学期结束！

欢迎参加SRTP项目的本科生加入本课题组

   目前学校第十四期大学生科研训练计划（SRTP）开始项目申报工作，欢迎高分子、材料、化工、化学和生物等专业的本科生加入本课题组进行科研训练！具体通知请见下列链接：本科生院关于组织申报和实施浙江大学第十四期大学生科研训练计划（SRTP）项目的通知。     本课题组当前的主要研究方向是组织修复与再生医用高分子材料研究，包括组织工程与再生医学材料、纳米与胶体生物材料及其与细胞的相互作用。指导思想是采用材料和化学的手段和技术解决组织修复和再生的基础和应用问题，提供用于皮肤、软骨、骨和肝等治疗的材料与技术。可以分为以下四个主要研究方向： （1） 组织修复与再生医用高分子材料 （2） 细胞迁移与分化诱导材料 （3） 胶体微粒与细胞的相互作用 （4） 自组装微胶囊