Postdoc fellow recruitment in Prof. Changyou Gao’s lab in Zhejiang University

Postdoc fellow recruitment in Prof. Changyou Gao’s lab in Zhejiang University   Changyou Gao, Ph.D, Professor, Chair of Department of Polymer Science and Engineering, Zhejiang University. He was awarded with the National Science Fund Award for Distinguished Young Scholars of China in 2004, and was appointed as a Changjiang Scholar of the Ministry of Education in 2007. He was elected as a fellow of the American Institute for Medical and Biological Engineering (AIMBE) in 2017, and a fellow of the International Union of Societies of Biomaterials Science and Engineering (FBSE) in 2016. His research is focused on the development of biomaterials for tissue engineering and regenerative medicine (myocardic infarction, perpheral and central nerves, blood vessel, cartilage and subchondral bone, and dermis), and colloidal biomaterials and their cellular interactions. In recent years he has been focusing on the tissue-microenvironment-responsive polymers, self-adaptive biomaterials for tissue regeneration, and gradient biomaterials for mediating cell migration and differentiation. He has published about 70 granted patents, 11 books/book chapters, and over 400 papers in pear-reviewed journals (WOS H-index 62, citations > 10,000). The majors of postdoc candidates: polymer synthesis; cell biology. Research works: Design and synthesis of tissue microenvironment-responsive polymers; Immune-modulation of self-adaptive biomaterials in vitro and in vivo. Salary: 180 k RMB/year or high. Duration: 2-6 years, negotiable. Contact, Prof. Changyou Gao, cygao@zju.edu.cn. PS: Candidates with other backgrounds such as polymer materials or processing, chemistry, biomaterials science and engineering, materials surfaces and interfaces, intelligent materials, nanomaterials, colloidal materials, medicinal devices, tissue engineering, regenerative medicine, cell biology, animal experiments, or clinical medicine are welcome to send your CVs for references.

International Forum of Biomedical Materials: Biomaterial surfaces and Interfaces——1st circular

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Dual-Imaging Of Nano/Microsized Theranostics Workshop

Time：June 23, 2016 (Thursday) Location：Seminar room, Polymer Building, Zhejiang University   Time Title Speaker 8:30-8:35 Opening Speech Prof. Changyou Gao 8:35-9:00 Report of WP2: Functionalization of biopolymer particles Dr. Weijun Tong 9:00-9:30 Report of WP3 : Functionalization of red blood cells Prof. Radostina Georgieva 9:30-9:50 Red blood cells as carriers for HSA-coated superparamagnetic iron-oxide nanoparticles Waraporn Kaewprayoon 9:50-10:10 Enhanced cellular uptake of bowl-like microcapsules   Huiying Li   10:10-10:40 Coffee Break 10:40-11:00 Determination of hemoglobin concentration microparticles  Chiraphat Kloypan 11:00-11:20 Porphyrin micro-nano particles mimicking viral morphology for enhanced endocytosis and Photodynamic Therapy   Wenbo Zhang   11:20-11:40 Entrapment and release of riboflavin from biopolymer submicro particles.   Nittiya Suwannasom 11:40-12:00   Suppress the cytotoxicity caused by CuO nanoparticles   Yixian Zhang 12:00-15:30 Lunch 15:30-16:00 Report from SSU Prof. Dmitry Gorin 16:00-16:30 Contributions of UGent (BE) in the EU Marie-Curie IRSES project “DINaMIT” Prof.Andre Skirtach 16:30-17:00 Report from UNIPMN Prof. Ciro Isidoro 17:00-17:30 Report from UNITO Prof.Enzo Terreno 17:30-18:00 Management, Collaboration and Dissemination Prof. Hans Bäumler 18:00 Dinner  

International Forum of Biomedical Materials

The 10th World Biomaterials Congress was held in Montreal

The 10th World Biomaterials Congress was held in Montreal during 17th May and 22nd May, this congress is dedicated topioneering biomaterials researchers acrossthe past four decades who have enabledinnovation in the field, delivering on emergingtechnologies for global medical solutions.   Four teachers and two PhD candidates from our group participated in this congress. Prof. Changyou Gao was awarded the lifelong honorary title “Fellow, Biomaterials Science and Engineering”(FBSE) by the International Union of Societies for Biomaterials Science and Engineering (IUSBSE). This honor recognizes that Prof. Gao has gained a status of excellent academic standing and high achievements in the field of biomaterials science and engineering. Prof. Changyou Gao gave an oral report named “Effect of chiral poly(acryloyl-valine) Capped on AuNPs on protein adsorption and cellular uptake” in “Intracellularly acting nano-structured biomaterials” and presented a poster named “Cell-free fibrin scaffolds for in situ regeneration of full thickness cartilage defects”. Prof. Lie Ma gave an oral report named “Gene-activated matrix for in situ regeneration of skin: from structure to function” in “Biomaterials in wound healing” general session. Wenbo Zhang presented a poster named “Porphyrin micro-nano particles mimicking viral morphology and influence of their roughness on endocytosis” and got an “ASV trainee award”. In addition, Weijun Tong presented a poster “Self-assembled Colloidal Particles with pH Sensing Property”, Zhengwei Mao presented a poster “Cell membrane capsules as biomimetic drug carriers”, and Shan Yu presented a poster “Preparation of MMP-sensitive Hyaluronic Acid Hydrogels and their impact on cell migration”.   Some of the graduated students of our group also took part in this congress. Yi Hong from University of Texas at Arlington gave an oral report “Synthesis and characterization of a conductive, biodegradable polyurethane elastomer” in “Biodegradable Polymers” session, and presented a poster named “Engineering a three-dimensional cancer model from lung extracellular matrix hydrogel”. Jianjun Guan from The Ohio StateUniversitypresented a poster named “A prosurvival and proangiogenic stem cell delivery system to promote ischemic limb regeneration”   4015 people from over 60 countries participated in this congress, the theme is Biomaterials for global medical solutions and emergingtechnologies, the presence of Industry and innovation in the numerous workshops, special sessions can be seen. Our group has got series of achievements like papers and patents in the past, and now we are still working hard to do research in biomaterials for the benefit of tissue repairing and regeneration, and we believe the future will be better.      

Postdoc fellow recruitment

Send your CV to Prof. Changyou Gao, cygao@zju.edu.cn.   Research project: Gradient polymeric biomaterials with stimuli-response for regulating the migration of cells The cell migration is one of the important processes in biology and physiology, and takes a pivotal role in immune response, would healing and tumor metastasis. While it is mediated by various gradient cues including biological, chemical, physical, and matrix signals, the cell milieu is in turn remodeled as a result of dynamic secretion of extracellular matrix by cells. In this study, intelligent and gradient polymeric biomaterials such as stimuli-responsive, adaptive and cell-selective gradient biomaterials shall be prepared and used to regulate cell migration in an intelligent manner. To better mimic the physiological milieu in vivo, the models of single cell, cell sheet and cell clusters shall be adopted to explore the phenomena, discipline and mechanism of cell migration on the intelligent and gradient biomaterials. Adsorption of key proteins and their spatial and time evolution on the gradient biomaterials before and after the intelligent response and cell culture shall be clarified, which can be further correlated with the cell migration behaviors to figure out the mediating methods and models of the intelligent and gradient biomaterials. The gradient biomaterials with spatially aligned physical features are intended to be applied for repair and regeneration of typical tissues such as blood vessel and nerve in vivo.     Research Project:Fabrication of responsive polymeric colloidal particles and their influences on cellular uptake and functions Understanding the correlation between the molecular structure and physicochemical properties of the responsive colloidal particles and their intracellular uptake and response is one of the most paramount perquisites for the applications. In this study, novel polymeric particles with tunable chemical structure and responsiveness to external stimuli (temperature, pH, ionic strength and biomolecular concentration) shall be designed and fabricated. Their in vitro cellular uptake and intracellular response process shall be clarified in terms of cellular uptake rate, amount, pathways and intracellular distribution. Studies also cover the responsiveness of the particles inside the cells. The alteration of cell viability, specific functions, phenotype and genetic toxicity shall be studied too. Cellular uptake and transportation principles shall be summarized and models shall be suggested. Finally, the in vivo tissue accumulation and alteration of the particles shall be studied in a rat model.  

The programme of CESB2015 has been released!

         The programme has been released, download address:   http://polymer.zju.edu.cn/cesb2015/index.php?m=Page&a=index&id=23

5th China-Europe Symposium on Biomaterials in Regenerative Medicine (CESB2015)-2nd Circular

Zhijiang Zhijiang Science Forum——3rd circular

Zhijiang Science Forum —International Forum of Biomedical Materials Nanobiomaterials and Biomaterials Interfaces

点击下载： 附件1：Abstrat Template 附件2：Registration Form-2014

Immobilization of Enzymes on 2-Hydroxyethyl Methacrylate and Glycidyl Methacrylate Copolymer Brushes

    The immobilization of enzymes is of paramount importance to maintain their activity and stability. In this study, surface-initiated atom transfer radical polymerization was applied to prepare poly(2-hydroxyethyl methacrylate)-b-poly(2-hydroxyethyl methacrylate-co-glycidyl methacrylate) brushes on glass slides. The polymerization kinetics was followed by quartz crystal microbalance with dissipation and ellipsometry in terms of mass and thickness growth, respectively. The surface chemical compositions of the obtained polymer brushes were characterized by X-ray photoelectron spectroscopy. Their mass, thickness and enzyme immobilization ability could be easily tuned by the initiator reaction time, monomer ratio and polymerization time. The anti-bacteria activity and stability of the immobilized lysozymes were studied by fluorescent staining and bacteria lysis assay, revealing that the lysozymes on the copolymer brushes had good stability against storage at 4oC for up to 30 days. Tanchen Ren, Zhengwei Mao*, Sergio Enrique Moya, Changyou Gao*, Immobilization of enzymes on 2-hydroxyethyl methacrylated and glycidyl methacrylate copolymer brushes, Chemistry-an Asian Journal, 2014. DOI: 10.1002/asia.201402150, IF: 4.572.    

A quantitative study of the intracellular concentration of graphene/noble metal nanoparticle composites and their cytotox

Noble-metal nanoparticles (NPs) especially prepared from gold and silver have been combined on the surface of graphene to obtain graphene-based nanocomposites for novel functions in enhanced performance in bio-imaging, cancer detection and therapy. However, little is known about their cellular uptake, especially the intracellular quantity which plays a critical role in determining their functions and safety. Therefore, we prepared covalently conjugated GO/Au and GO/Ag composites by immobilizing Au and Ag nanoparticles on GO sheets pre-functionalized with disulfide bonds, respectively. The cellular uptake of these composites was quantitatively studied by means of an ion beam microscope (IBM) to determine the metal content in human lung cancer cells (A549 cells) and liver hepatocellular carcinoma cells (HepG2 cells). The cell uptake was also studied by inductively coupled plasma mass spectrometry (ICP-MS), which is one of the most sensitive techniques being applied to cell suspensions, for comparison. Toxicity, one of the consequences of cellular uptake of GO based composites, was studied as well. The potential toxicity mechanism was also suggested based on the results of intracellular quantification of the nanomaterials.   Xiangyan Zhou, Marco Dorn, Jürgen Vogt, Daniel Spemann, Wei Yu, Zhengwei Mao,* Irina Estrela-Lopis, Edwin Donath and Changyou Gao. A quantitative study of the intracellular concentration of graphene/noble metal nanoparticle composites and their cytotoxicity. Nanoscale, 2014, DOI: 10.1039/C4NR01763C            

Group Members Attended TERMIS-AP 2013 Annual Conference

    Tissue Engineering and Regeneration Medicine International Society-AP annual conference(TERMIS-AP) is Annual international event of the field of tissue engineering and regeneration medicine, is the most influential academic conference in Asian-Pacific region. There are many countries such as Australia, Korea, Singapore having held Asia-Pacific conference successfully. In the efforts of Pro. Yilin Cao and Pro. Wei Liu 2010,China has obtained the host of TERMIS-AP 2013 Annual Conference.     The conference was held in Wuzhen and Shanghai during 23-26 Oct,2013. Attracted by the conference, numberous experts and scholars from colleges, universities, research institutions, hospitals,companies both at home and abroad gathered and explored the latest research and progress in stem cells, biomaterials, bioreactors, biomechanics et al. Pro.David Williams, academician Zhang Xingdong, academician Dai Kerong and other well-known experts and professors were invited to give a meeting lecture. Based on the purpose of combining research with clinical application, this conference built an international communication platform for those involving in tissue engineering, medicine, molecular biology, cytobiology.      Prof. Changyou Gao, Prof. Lie Ma, and students including Tanchen Ren, Pengfei Jiang, Dongming Xing, Shan Yu, Sai Wu attended the conference. Pro. Gao presided over the special report named “Biopolymer”, and gave an invited speech about Designed Biomaterials for the in situ Tissue Regeneration and Cell Migration, which won the high evaluation from counterparts at home and abroad.     Pro. Ma gave an oral report about Skin Scarless Repair by a Collagen/Chitosan-Silicone Membrane Bilayered Dermal Equivalent: a Gene-Silencing Strategy.     Besides, group students had a excellent performance in this conference. Tanchen Ren gave an oral report “Cell migration guided by poly(2-hydroxylethyl methacrylate) thickness gradient”. Dongming Xing reported Biodegradable Polyesters with Pendant Neurotransmitter for Neural Tissue engineering. Pengfei Jiang reported Influence of Polymeric Particles Internalization on Mesenchymal Stem Cell Differentiation. Shan Yu gave a presentation named Cell Migration Guided By Gelatin Density Gradient On PCL Membranes. Sai Wu gave an oral named Role of Adsorbed Serum Proteins on Hydroxyapatite-coated Titanium in Cell Morphology and Adhesion.     Through active participation in this conference, our group deepen the communication and cooperation with counterparts at home and abroad, expand the influence in the field of biomaterials, tissue engeneering and regeneration medicine.  

Fabrication of Red Blood Cell-like Polyelectrolyte Microcapsules and Their Deformation and Recovery Behaviors through a M

    Multilayer microcapsules with a biconcave discoidal shape mimicking the red blood cells (RBCs) were fabricated by covalent assembly of polyallylamine on RBC-like Ca(OH)2 particles, followed by core removal. Their morphology was verified by scanning electron microscopy and confocal laser scanning microscopy. Deformation of the 6.7 μm RBC-like capsules after being trapped into a 5 μm micro-capillary took place at the contacting parts with the capillary. They showed elastic deformation after liberated from the constriction, resulting in a high recovery ratio of ~90%. These capsules also could be endowed with reversible oxygen binding-releasing capacity by assembly of hemoglobin (Hb).     The paper < Fabrication of Red Blood Cell-like Polyelectrolyte Microcapsules and Their Deformation and Recovery Behaviors through a Micro-capillary > was published on Advanced Materials.( SCI Impact factor: 14.829)   Shupeng She, Qinqin Li, Bowen Shan, Weijun Tong*, Changyou Gao*. Fabrication of Red Blood Cell-like Polyelectrolyte Microcapsules and Their Deformation and Recovery Behaviors through a Micro-capillary. Advanced Materials. DOI: 10.1002/adma. 201302875.