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计剑 教授

日期:2010-03-23 22:10
计   剑 教授

计剑(教授,博士生导师)

    1992年毕业于浙江大学化学系并获得学士学位,1997年获高分子化学与物理博士学位,2004年晋升教授,2008年任浙江大学生物医用大分子研究所副所长。主要从事生物医用材料的应用基础研究,在生命体系与材料界面的生物相容性和生物功能性方面开展了系统深入的研究,形成了采用过程仿生的自组装行为制备具有结构和功能仿生的新型生物材料的研究特色,并将该原理应用到现代介入医用材料和组织工程材料的设计和研发中。

    在包括Advanced Materials, Biomaterials, Langmuir等核心期刊发表SCI, EI收录论文90余篇,影响因子大于6.0的10篇, 大于3.0的36篇,获国家发明专利12项 。是我国具有自主知识产权的心动系列细胞膜仿生药物涂层支架的主要发明人。

获奖及荣誉
2000年    第六届世界生物材料大会杰出博士后旅行奖。
2002年    第十七届欧洲生物材料大会优秀青年科学家奖
2004年    国家教育部霍英东基金优选资助项目
2005年    国家教育部“新世纪优秀人才支持计划”
2010年    获国家杰出青年科学基金资助

工作研究领域
1)心血管医用材料和微创介入医用材料
2)医用材料的组织工程化设计
3)生物治疗用智能纳米微载体
4)新型固相基因传递体系的研究
5)仿生双亲聚合物的溶液和界面组装
6)层层组装构建生物相容性和生物功能性纳米层状超薄膜的研究

联系方式
电话:0571-87953729
电子信箱:
jijian@zju.edu.cn
浙江大学个人主页链接
http://mypage.zju.edu.cn/biointerface 

Professor Dr. Ji Jian
Dr. Jijian received a bachelor’s degree at Chemistry Department of Zhejiang University in 1992. He joined the department in 1997 after getting his PhD degree in the Institute of Polymer composites of Zhejiang University in 1997, and became an associated professor and full professor in 2000 and 2004, respectively. He teaches two undergraduate courses related to the polymeric composite and functional polymer and one Ph. D course related to polymer surface and interface. He has been doing research work in the polymeric biomaterials and biological interface for over 10 years and has published more than 50 research papers in peer reviewed international Journal.
His main research interest focuses on polymeric biomaterials and biological interface. Based on the biomimic strategy, several supramolecular self-assemble methods were explored to develop biocompatible and biofunctional materials. Electrostatic self –assembly” method, which based on the alternating physisorption of oppositely charged polyelectrolytes, was explored to develop several functional multilayer coating onto biomaterial to represent the desirable properties, such as anti-coagulation, promote cytocompatibility and control release of DNA. In following the biological perspective of glycocalyx, the poly(ethylene oxide) comb-like copolymers were explored to engineer glycocalyx-mimic surfaces, which reduce the non-specific interaction and end-tethered ligand to trigger biomolecules self-assemble. Get inspiration of the cell membrane structure, a kind of cell membrane biomimetic micelles were developed via supramolecular aggregation of a biomimetic amphiphilies. The biomimetic nano-carriers show low toxicity and high cell uptake ratio, which might be suitable as a carrier vehicle for delivering bioactive agents.
 
Current Projects:

* Development of Advanced Biomimetic Biomaterial via Self-assembly
* Surface Modification for Cardiovascular Biomaterial
* Design of Signaling Surface to Trigger Cell Behavior
* Development of Polymer-based Gene Delivery System via Self-assembly
* Novel Biomimetic Polymeric Nano-Carrier for Drug delivery

Contact:

Professor, Dr. Ji jian 
Institute of Biomedical Macromolecules, 
Department of Polymer Science and Engineering,
Zhejiang University, Hangzhou 310027 China
Email: jijian@zju.edu.cn
Tel: 86-571-87953729



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